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Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event.

作者信息

Boland M P, Foster S J, O'Neill L A

机构信息

Biochemistry Department, Trinity College Dublin, Ireland, UK.

出版信息

Biochem Soc Trans. 1996 Feb;24(1):1S. doi: 10.1042/bst024001s.

DOI:10.1042/bst024001s
PMID:8674577
Abstract
摘要

相似文献

1
Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event.尽管未观察到鞘磷脂酶信号事件，但在白血病细胞系中神经酰胺类似物可激活核因子κB并增强肿瘤坏死因子诱导的核因子κB激活。
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Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.肿瘤坏死因子激活鞘磷脂途径可促使完整的HL-60细胞中的核因子κB发生易位。
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Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.肿瘤坏死因子-α通过神经酰胺依赖性丝裂原活化蛋白激酶和IκB激酶1/2的顺序激活诱导人肺泡上皮细胞中环氧化酶-2的表达。
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Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha.滑膜成纤维细胞与鞘磷脂酶途径：鞘磷脂周转和神经酰胺生成并非肿瘤坏死因子-α作用的信号传导机制。
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Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.胰岛素抵抗的脂质介质：神经酰胺信号传导下调3T3-L1脂肪细胞中GLUT4基因的转录。
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TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.
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Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.蛋白激酶Cζ亚型对于鞘磷脂酶介导的κB依赖性启动子激活至关重要。
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Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-alpha in human glial cells.HIV-1 Nef对肿瘤坏死因子-α在人神经胶质细胞中激活的鞘磷脂转导途径的干扰。
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Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B.抑制神经酰胺途径不影响肿瘤坏死因子-α激活核因子-κB的能力。
J Immunol. 1994 Jun 15;152(12):5877-82.

引用本文的文献

1
Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases.视网膜内皮细胞中鞘氨醇激酶的药理学调控：对眼部血管生成性疾病的影响
Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5022-31. doi: 10.1167/iovs.05-1236.
2
The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen.鞘磷脂 - 神经酰胺途径参与细胞因子对C反应蛋白和血清淀粉样蛋白A的调节，但不参与对α - 纤维蛋白原的调节。
Biochem J. 1997 Nov 15;328 ( Pt 1)(Pt 1):271-5. doi: 10.1042/bj3280271.