Nishijima S, Nakagawa M, Tsuboi N, Akamatsu H, Horio T, Fujita M, Kawabata S
Division of Dermatology, Kansai Medical University, Kori Branch Hospital, Osaka, Japan.
J Int Med Res. 1996 Jan-Feb;24(1):12-6. doi: 10.1177/030006059602400102.
The in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to nadifloxacin and seven other fluoroquinolones (norfloxacin, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin and sparfloxacin) was evaluated. The MRSA isolates were isolated from 114 skin infections between 1991 and 1994. Nadifloxacin exhibited the lowest minimum inhibitory concentration and there were no MRSA isolates resistant to nadifloxacin, while there were some resistant to all of the other seven fluoroquinolones. The minimum concentrations of these drugs needed to cause 50% inhibition of the isolates increased dramatically from 1991 to 1992, but has hardly changed since 1992.
评估了耐甲氧西林金黄色葡萄球菌（MRSA）对那氟沙星及其他七种氟喹诺酮类药物（诺氟沙星、氧氟沙星、依诺沙星、环丙沙星、洛美沙星、妥舒沙星和司帕沙星）的体外敏感性。这些MRSA分离株于1991年至1994年间从114例皮肤感染中分离得到。那氟沙星表现出最低的最低抑菌浓度，且没有对那氟沙星耐药的MRSA分离株，而对其他七种氟喹诺酮类药物均有一些耐药菌株。从1991年到1992年，引起这些分离株50%抑制所需的这些药物的最低浓度急剧增加，但自1992年以来几乎没有变化。
