A-56619、A-56620、阿米氟沙星、环丙沙星、依诺沙星、诺氟沙星和氧氟沙星对耐甲氧西林金黄色葡萄球菌的体外比较
In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus.
作者信息
Smith S M
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):325-6. doi: 10.1128/AAC.29.2.325.
Abstract
Seven quinolone antibiotics were tested against 115 isolates of methicillin-resistant Staphylococcus aureus. The MICs for 90% of the strains tested were 0.5 microgram/ml for A-56619, A-56620, ciprofloxacin, and ofloxacin; 2.0 micrograms/ml for amifloxacin and enoxacin; and 4.0 micrograms/ml for norfloxacin. Killing kinetic studies showed a similar killing rate for all seven antibiotics.
摘要
对115株耐甲氧西林金黄色葡萄球菌菌株测试了七种喹诺酮类抗生素。对于所测试的90%的菌株，A-56619、A-56620、环丙沙星和氧氟沙星的最低抑菌浓度（MIC）为0.5微克/毫升；阿米氟沙星和依诺沙星为2.0微克/毫升；诺氟沙星为4.0微克/毫升。杀菌动力学研究表明，所有七种抗生素的杀菌速率相似。
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