为什么肠道腔内会存在表皮生长因子？
Why is epidermal growth factor present in the gut lumen?
作者信息
Playford R J, Wright N A
机构信息
Department of Gastroenterology, Leicester General Hospital.
出版信息
Gut. 1996 Mar;38(3):303-5. doi: 10.1136/gut.38.3.303.
Abstract
The jury is still out on the role of luminal EGF in the normal gastrointestinal tract. Recent evidence, however, suggests that its major function is to act as a 'luminal surveillance' peptide, which is available to stimulate repair and that it is not of major importance in maintaining normal gut growth. Recombinant EGF administered via the gut lumen could still prove a valuable tool for the treatment of gastrointestinal ulceration. Perhaps the old term for EGF, 'epidermal healing factor' or EHF, was more appropriate after all!
摘要
关于腔内表皮生长因子（EGF）在正常胃肠道中的作用尚无定论。然而，最近的证据表明，其主要功能是作为一种“腔内监测”肽，可用于刺激修复，并且在维持肠道正常生长方面并非至关重要。经肠腔给予重组表皮生长因子仍可能是治疗胃肠道溃疡的一种有价值的工具。也许表皮生长因子的旧称“表皮愈合因子”（EHF）终究更为恰当！
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