Tchilian E Z, Owen J J, Jenkinson E J
Centre for Clinical Research in Immunology and Signalling/Department of Anatomy, Medical School, University of Birmingham, UK.
Immunology. 1997 Nov;92(3):321-7. doi: 10.1046/j.1365-2567.1997.00351.x.
We have shown that an antibody (9C10) to the alpha 4 integrin induces apoptosis in murine immature CD4+ CD8+ thymocytes and in activated (but not resting) mature lymph node T cells. In both cases, apoptosis is blocked by the highly selective protein kinase C (PKC) inhibitor Ro31.8425, suggesting that 9C10 induces signalling through the alpha 4 integrin resulting in PKC activation leading to apoptosis. Overall, our results indicate the potential role of the alpha 4 integrin-mediated interactions in apoptosis induction during T-cell development and following mature T-cell activation.
我们已经证明,一种针对α4整合素的抗体(9C10)可诱导小鼠未成熟CD4+CD8+胸腺细胞以及活化的(而非静止的)成熟淋巴结T细胞发生凋亡。在这两种情况下,凋亡均被高选择性蛋白激酶C(PKC)抑制剂Ro31.8425阻断,这表明9C10通过α4整合素诱导信号传导,导致PKC活化并进而引发凋亡。总体而言,我们的结果表明α4整合素介导的相互作用在T细胞发育过程以及成熟T细胞活化后诱导凋亡中具有潜在作用。