[14C-nicotinate and 35S-thiamine distribution in the bodies of mice following acceleration].

Radioactivity of some tissues and subcellular fractions of the liver was studied in the control mice and those subjected to the action of acceleration at the different times after intra-abdominal injections of 35S-thiamine and 14C-nicotinate. The vitamins injections were single 20 min after the effect of overload. The overload is established to evoke essential changes in interorgan and intracellular distribution of the vitamins under study, 35S-thiamine in particular. At early periods of the experiment (5-20 min) after injection of 35S-thiamine radioactivity is observed to increase radioactivity in most tissues. In experiments with 14C-nicotinate the changes towards both an increase and decrease in radioactivity of certain tissues are marked to be less essential. The changes in the metabolic processes and permeability of biomembranes under conditions of overload action are a possible reason of the mentioned disturbances.