Schmitz S A, Mühler A, Wagner S, Wolf K J
Department of Radiology and Nuclear Medicine, Benjamin Franklin University Hospital Steglitz, Free University of Berlin, Germany.
Invest Radiol. 1996 Mar;31(3):154-60. doi: 10.1097/00004424-199603000-00006.
Gadolinium-EOB-DTPA (Gd-EOB-DTPA) is a hepatobiliary magnetic resonance (MR) imaging contrast medium designed to detect focal liver lesions. The objective of this study was to evaluate dynamic Gd-EOB-DTPA-enhanced MR imaging as a new method for assessing liver excretory function and to compare it with a scintigraphic method, the gold standard.
Changes in scintigraphic liver activity or MR liver signal intensity were intraindividually monitored over time after intravenous injection of 50 mumol Gd/kg of Gd-EOB-DTPA in controls and rats with common bile duct obstruction or L-ethionine-induced fatty liver (n = 6).
A comparison of liver scintigraphy and MR imaging revealed that elimination half-lives of Gd-EOB-DTPA were significantly longer in rats with common bile duct obstruction (scintigraphy: 100 +/- 27 minutes; MR imaging: 59 +/- 18 minutes) or fatty liver (scintigraphy: 94 +/- 30 minutes; MR imaging: 72 +/- 32 minutes) than in controls (scintigraphy: 20 +/- 2 minutes; MR imaging: 18 +/- 3) (P < 0.05).
Like liver scintigraphy, functional MR liver imaging using Gd-EOB-DTPA is feasible and can differentiate normal controls from models of biliary and hepatocyte disease.
钆塞酸二钠（Gd-EOB-DTPA）是一种用于检测肝脏局灶性病变的肝胆磁共振（MR）成像造影剂。本研究的目的是评估动态Gd-EOB-DTPA增强MR成像作为评估肝脏排泄功能的新方法，并将其与作为金标准的闪烁扫描法进行比较。
在对照组以及胆总管梗阻或L-乙硫氨酸诱导的脂肪肝大鼠（n = 6）静脉注射50 μmol Gd/kg的Gd-EOB-DTPA后，随时间对个体内闪烁扫描肝脏活性或MR肝脏信号强度的变化进行监测。
肝脏闪烁扫描与MR成像的比较显示，胆总管梗阻大鼠（闪烁扫描：100±27分钟；MR成像：59±18分钟）或脂肪肝大鼠（闪烁扫描：94±30分钟；MR成像：72±32分钟）中Gd-EOB-DTPA的消除半衰期显著长于对照组（闪烁扫描：20±2分钟；MR成像：18±3分钟）（P < 0.05）。
与肝脏闪烁扫描一样，使用Gd-EOB-DTPA的功能性MR肝脏成像可行，并且可以区分正常对照组与胆道和肝细胞疾病模型。
