Jeng C Y, Sheu W H, Fuh M M, Shieh S M, Chen Y D, Reaven G M
Department of Medicine, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
J Clin Endocrinol Metab. 1996 Jul;81(7):2550-3. doi: 10.1210/jcem.81.7.8675576.
Gemfibrozil or placebo was administered for 3 months to 24 individuals with endogenous hypertriglyceridemia and normal glucose tolerance. Mean ( +/- SEM) fasting plasma triglyceride (TG) concentrations decreased (4.01 +/- 0.55 to 1.34 +/- 0.12 mmol/L; P < 0.001) and high density lipoprotein cholesterol concentrations increased (0.54 +/- 0.03 to 0.67 +/- 0.04 mmol/L; P < 0.001) in gemfibrozil-treated patients, associated with lower (P < 0.01-0.001) plasma free fatty acid and TG concentrations when measured at hourly intervals in response to breakfast (0800 h) and lunch (1200 h). However, day-long plasma glucose and insulin responses to meals in the 2 groups were similar before and after treatment, as were the steady state plasma glucose and insulin concentrations at the end of a 180-min infusion of somatostatin, insulin, and glucose. Thus, marked decreases in both plasma TG and free fatty acid concentrations seen in association with gemfibrozil neither enhanced insulin-mediated glucose disposal nor lowered ambient plasma insulin concentrations in patients with endogenous hypertriglyceridemia.
将吉非贝齐或安慰剂给予24名内源性高甘油三酯血症且糖耐量正常的个体，为期3个月。在接受吉非贝齐治疗的患者中，空腹血浆甘油三酯（TG）平均浓度（±标准误）下降（从4.01±0.55降至1.34±0.12 mmol/L；P<0.001），高密度脂蛋白胆固醇浓度升高（从0.54±0.03升至0.67±0.04 mmol/L；P<0.001），且在早餐（08:00）和午餐（12:00）后按小时间隔测量时，血浆游离脂肪酸和TG浓度较低（P<0.01 - 0.001）。然而，两组患者在治疗前后对餐食的全天血浆葡萄糖和胰岛素反应相似，在输注生长抑素、胰岛素和葡萄糖180分钟结束时的稳态血浆葡萄糖和胰岛素浓度也相似。因此，在患有内源性高甘油三酯血症的患者中，与吉非贝齐相关的血浆TG和游离脂肪酸浓度显著降低，既未增强胰岛素介导的葡萄糖处置，也未降低周围血浆胰岛素浓度。
