Si S H, Xu Y J, Nie L H, Yao S Z
New Material Research Institute, Hunan University, Changsha, PR China.
J Biochem Biophys Methods. 1996 Feb 5;31(3-4):135-43. doi: 10.1016/0165-022x(95)00031-l.
A method of using a bulk acoustic wave (BAW) device to study the hemorheological phenomena is proposed. By measuring the resonant resistance of a BAW device, the dependence of the plasma viscosity on its composition is investigated. It has been found that during the process of the plasma coagulation, the frequency response of a BAW device is dominated by the change in plasma viscoelasticity, and useful information such as the coagulation time and the viscoelasticity of coagulated plasma can be obtained from the curve of frequency response. Based on the BAW quartz detection system, effects of fibrinogen, thrombin and some drugs on the plasma coagulation are investigated. The results show that the BAW device based on the oscillator method possesses some advantages, such as high sensitivity, simplicity of use, cost effectiveness and small sample volume for clinical hemorheological study.
提出了一种利用体声波（BAW）器件研究血液流变学现象的方法。通过测量BAW器件的谐振电阻，研究了血浆粘度对其成分的依赖性。研究发现，在血浆凝固过程中，BAW器件的频率响应主要受血浆粘弹性变化的影响，并且可以从频率响应曲线中获得诸如凝固时间和凝固血浆粘弹性等有用信息。基于BAW石英检测系统，研究了纤维蛋白原、凝血酶和一些药物对血浆凝固的影响。结果表明，基于振荡器方法的BAW器件具有一些优点，如高灵敏度、使用简单、成本效益高以及用于临床血液流变学研究的样本量小。
