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J Virol. 1996 Jul;70(7):4854-7. doi: 10.1128/JVI.70.7.4854-4857.1996.

2

The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus.抗病毒化合物恩韦肟作用于鼻病毒和脊髓灰质炎病毒的3A编码区。

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本文引用的文献

1

Studies with poliovirus polymerase 3Dpol. Stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB.使用脊髓灰质炎病毒聚合酶3Dpol的研究。纯化的脊髓灰质炎病毒蛋白3AB在体外对聚（U）合成的刺激作用。

J Biol Chem. 1994 Nov 18;269(46):29173-81.

2

A role for 3AB protein in poliovirus genome replication.3AB蛋白在脊髓灰质炎病毒基因组复制中的作用。

J Biol Chem. 1995 Jun 16;270(24):14430-8. doi: 10.1074/jbc.270.24.14430.

3

The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus.抗病毒化合物恩韦肟作用于鼻病毒和脊髓灰质炎病毒的3A编码区。

J Virol. 1995 Jul;69(7):4189-97. doi: 10.1128/JVI.69.7.4189-4197.1995.

4

Mutations in the hydrophobic domain of poliovirus protein 3AB abrogate its permeabilizing activity.脊髓灰质炎病毒蛋白3AB疏水结构域中的突变消除了其通透活性。

FEBS Lett. 1995 Jun 19;367(1):5-11. doi: 10.1016/0014-5793(95)00523-c.

5

Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus.脊髓灰质炎病毒基因组连接蛋白VPg的膜依赖性尿苷酸化

Proc Natl Acad Sci U S A. 1983 Dec;80(24):7447-51. doi: 10.1073/pnas.80.24.7447.

6

ATP is required for initiation of poliovirus RNA synthesis in vitro: demonstration of tyrosine-phosphate linkage between in vitro-synthesized RNA and genome-linked protein.体外脊髓灰质炎病毒RNA合成起始需要ATP：体外合成的RNA与基因组连接蛋白之间酪氨酸磷酸键的证明。

J Virol. 1984 May;50(2):515-23. doi: 10.1128/JVI.50.2.515-523.1984.

7

Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides.在脊髓灰质炎病毒RNA复制中具有活性的膜组分含有VPg前体多肽。

Virology. 1983 Jul 15;128(1):33-47. doi: 10.1016/0042-6822(83)90316-1.

8

A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide.通过用针对合成七肽的抗体进行免疫沉淀鉴定出的脊髓灰质炎病毒VPg的膜相关前体。

Cell. 1982 Feb;28(2):405-12. doi: 10.1016/0092-8674(82)90358-0.

9

The role of cytoplasmic membranes in poliovirus biosynthesis.细胞质膜在脊髓灰质炎病毒生物合成中的作用。

Virology. 1970 Sep;42(1):100-11. doi: 10.1016/0042-6822(70)90242-4.

10

Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells.脊髓灰质炎病毒正链RNA在受感染的HeLa细胞膜复合物中的合成起始

J Virol. 1986 Oct;60(1):43-53. doi: 10.1128/JVI.60.1.43-53.1986.

鼻病毒和肠道病毒中3A介导的对环戊烯肟抗性的序列决定因素。

Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enteroviruses.

作者信息

Heinz B A, Vance L M

机构信息

Infectious Disease Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.Heinz_Beverly_A@Lilly,com

出版信息

J Virol. 1996 Jul;70(7):4854-7. doi: 10.1128/JVI.70.7.4854-4857.1996.

DOI:10.1128/JVI.70.7.4854-4857.1996

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190432/

Abstract

Using site-directed mutagenesis of the 3A coding region of rhinovirus 14, we have expanded our analysis of resistance to enviroxime. We have observed that high and low levels of drug resistance involve two domains within 3A and that the amino acid at position 30 is critical in determining resistance.

摘要

利用对鼻病毒14的3A编码区进行定点诱变的方法，我们扩展了对enviroxime耐药性的分析。我们观察到，高耐药水平和低耐药水平涉及3A内的两个结构域，并且30位氨基酸在决定耐药性方面至关重要。