鼻病毒和肠道病毒中3A介导的对环戊烯肟抗性的序列决定因素。
Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enteroviruses.
作者信息
Heinz B A, Vance L M
机构信息
Infectious Disease Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.Heinz_Beverly_A@Lilly,com
出版信息
J Virol. 1996 Jul;70(7):4854-7. doi: 10.1128/JVI.70.7.4854-4857.1996.
Abstract
Using site-directed mutagenesis of the 3A coding region of rhinovirus 14, we have expanded our analysis of resistance to enviroxime. We have observed that high and low levels of drug resistance involve two domains within 3A and that the amino acid at position 30 is critical in determining resistance.
摘要
利用对鼻病毒14的3A编码区进行定点诱变的方法，我们扩展了对enviroxime耐药性的分析。我们观察到，高耐药水平和低耐药水平涉及3A内的两个结构域，并且30位氨基酸在决定耐药性方面至关重要。
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