Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E
Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain.
JPEN J Parenter Enteral Nutr. 1996 Mar-Apr;20(2):145-9. doi: 10.1177/0148607196020002145.
Both epidemiologic and in vitro studies have indicated the inverse correlation between intake and/or blood concentrations of different carotenoids, retinol, and tocoferol with different chronic and degenerative disturbances (cancer, cardiovascular diseases, cataracts, aging). The purpose of this study was to determine the fat-soluble vitamin and carotenoid levels in men with recently diagnosed cancer of the larynx (n = 51) who had undergone total or partial laryngectomy and compare them with those of an age- and sex-matched control group (n = 51). In addition, the effects of commercial enteral formula feeding were assessed in a subgroup of these patients (n = 35).
A validated high-performance liquid chromatography method was used to determine the concentrations of six carotenoids (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and beta-carotene), retinol, and alpha-tocopherol in serum. Commercial, rather than blender prepared, enteral formulas were supplied to the patients as the only food source for an average period of 12 days. The statistical analysis was based on nonparametric methods (Mann-Whitney and Wilcoxon).
The levels of all compounds analyzed were significantly lower in men with laryngeal cancer than in the control group. Retinol and tocopherol increased significantly after enteral formula feeding, although they continued to be significantly lower than those of the controls. The carotenoid levels decreased after enteral nutrition.
The retinol and carotenoid concentrations should be monitored on a routine basis in these patients because of their relationship to this type of cancer. Moreover, it would be of interest to assess the effects of the addition of carotenoids to enteral formulas because they may offer protection from oxidative damage and potentiate the immune system.
流行病学和体外研究均表明，不同类胡萝卜素、视黄醇和生育酚的摄入量及/或血液浓度与不同的慢性和退行性疾病（癌症、心血管疾病、白内障、衰老）呈负相关。本研究的目的是测定近期诊断为喉癌且已接受全喉或部分喉切除术的男性患者（n = 51）的脂溶性维生素和类胡萝卜素水平，并将其与年龄和性别匹配的对照组（n = 51）进行比较。此外，还对这些患者中的一个亚组（n = 35）评估了商业肠内营养制剂喂养的效果。
采用经过验证的高效液相色谱法测定血清中六种类胡萝卜素（叶黄素、玉米黄质、β - 隐黄质、番茄红素、α - 胡萝卜素和β - 胡萝卜素）、视黄醇和α - 生育酚的浓度。向患者提供商业而非自制的肠内营养制剂作为唯一食物来源，平均持续12天。统计分析基于非参数方法（曼 - 惠特尼检验和威尔科克森检验）。
喉癌男性患者中所有分析化合物的水平均显著低于对照组。肠内营养制剂喂养后，视黄醇和生育酚显著升高，尽管仍显著低于对照组。肠内营养后类胡萝卜素水平下降。
鉴于这些患者的视黄醇和类胡萝卜素浓度与这类癌症的关系，应定期监测。此外，评估在肠内营养制剂中添加类胡萝卜素的效果可能会很有意义，因为它们可能提供抗氧化损伤保护并增强免疫系统。
