Endo T, Ikeo K, Gojobori T
National Institute of Genetics, Mishima, Japan.
Mol Biol Evol. 1996 May;13(5):685-90. doi: 10.1093/oxfordjournals.molbev.a025629.
We conducted a systematic search for the candidate genes on which positive selection may operate, on the premise that for such genes the number of nonsynonymous substitution is expected to be larger than that of synonymous substitutions when the nucleotide sequences of genes under investigation are compared with each other. By obtaining 3,595 groups of homologous sequences from the DDBJ, EMBL, and GenBank DNA sequence databases, we found that 17 gene groups can be the candidates for the genes on which positive selection may operate. Thus, such genes are found to occupy only about 0.5% of the vast number of gene groups so far available. Interestingly enough 9 out of the 17 gene groups were the surface antigens of parasites or viruses.
我们进行了一项系统搜索，寻找可能受到正选择作用的候选基因，前提是当比较所研究基因的核苷酸序列时，此类基因的非同义替换数量预计会大于同义替换数量。通过从DDBJ、EMBL和GenBank DNA序列数据库中获取3595组同源序列，我们发现有17个基因组可能是受到正选择作用的基因的候选者。因此，发现此类基因仅占目前可用的大量基因组的约0.5%。有趣的是，这17个基因组中有9个是寄生虫或病毒的表面抗原。
