Shabert J K, Wilmore D W
Brigham and Women's Hospital, Boston, MA 02115, USA.
Med Hypotheses. 1996 Mar;46(3):252-6. doi: 10.1016/s0306-9877(96)90251-0.
Tissue wasting often occurs during human immunodeficiency virus infection and acquired immune deficiency syndrome. While weight-loss in the human immunodeficiency virus-infected individual can be seen as an isolated symptom, catabolism during acquired immune deficiency syndrome is usually associated with complications such as diarrhea, malabsorption, fever and secondary infection. Glutamine is an amino acid central to many important metabolic pathways and recent findings suggest that glutamine depletion may explain the progression of tissue wasting during human immunodeficiency virus infection.
在人类免疫缺陷病毒感染和获得性免疫缺陷综合征期间，组织消耗经常发生。虽然在感染人类免疫缺陷病毒的个体中体重减轻可被视为一种孤立症状，但获得性免疫缺陷综合征期间的分解代谢通常与腹泻、吸收不良、发热和继发感染等并发症相关。谷氨酰胺是许多重要代谢途径中的关键氨基酸，最近的研究结果表明，谷氨酰胺耗竭可能解释了人类免疫缺陷病毒感染期间组织消耗的进展。
