England B K, Grewal M, Bailey J L, Price S R
Renal Division, Emory University School of Medicine, Atlanta, Ga. 30322, USA.
Miner Electrolyte Metab. 1996;22(1-3):69-71.
Chronic renal failure (CRF) is frequently complicated by malnutrition and wasting. The loss of lean body mass in CRF is the result of accelerated protein and amino acid degradation. Both appear to occur via acidosis-induced, glucocorticoid-dependent processes. In skeletal muscle, acidosis stimulates the activity of the rate-limiting enzyme in branched-chain amino acid metabolism, branched-brain ketoacid dehydrogenase (BCKAD). The activation of BCKAD in acidosis is likely to be glucocorticoid-dependent.
慢性肾衰竭(CRF)常伴有营养不良和消瘦。CRF患者瘦体重的减少是蛋白质和氨基酸加速降解的结果。这两者似乎都是通过酸中毒诱导的、糖皮质激素依赖的过程发生的。在骨骼肌中,酸中毒会刺激支链氨基酸代谢中的限速酶——支链α-酮酸脱氢酶(BCKAD)的活性。酸中毒时BCKAD的激活可能依赖于糖皮质激素。