Hayashi M, Ishimori K, Maeda A, Watanabe T, Arai S, Okui T
Department of Veterinary Radiology, Rakuno Gakuen University, Ebetsu, Japan.
Mutat Res. 1996 Jun 10;352(1-2):117-21. doi: 10.1016/0027-5107(96)00017-6.
Immortalized cell lines from LEC strain (LEC) rats by SV40 large T antigen were more sensitive to X-irradiation than the cell lines from WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a steep decline at low doses and a shallow decline at high doses. On the contrary, the dose-response curves for LEC-derived cell lines showed no steep component; they were almost identical to the shallow component of the curves for WKAH-derived cells.
