源自LEC品系大鼠的成纤维细胞系中DNA合成对紫外线照射的抗性。

Resistance to UV-irradiation of DNA synthesis in fibroblast cell lines derived from LEC strain rats.

作者信息

Uehara K, Arai S, Okui T, Hayashi M

机构信息

Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.

出版信息

J Vet Med Sci. 1997 Jan;59(1):67-9. doi: 10.1292/jvms.59.67.

DOI:10.1292/jvms.59.67

PMID:9035083

Abstract

After UV-irradiation, no difference in the survival curves was observed among cell lines derived from LEC strain (LEC) rats and WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a sharp decline at lower doses and a mild decline at higher doses of UV-rays. In contrast, the dose-response curves in LEC-derived cell lines had no sharp component, and were almost identical to the mild component of the curves in WKAH-derived cells. These results show that DNA synthesis in the cell lines of LEC rats was more resistant to UV-irradiation than that of WKAH rats.

摘要

紫外线照射后，源自LEC品系（LEC）大鼠和WKAH品系（WKAH）大鼠的细胞系之间的存活曲线未观察到差异。WKAH衍生细胞中DNA合成抑制的剂量反应曲线在较低剂量的紫外线照射下急剧下降，在较高剂量下轻微下降。相比之下，LEC衍生细胞系中的剂量反应曲线没有急剧部分，并且几乎与WKAH衍生细胞系中曲线的轻微部分相同。这些结果表明，LEC大鼠细胞系中的DNA合成比WKAH大鼠的更耐紫外线照射。