Baca V, Sanchez-Vaca G, Martínez-Muñiz I, Ramírez-Lacayo M, Lavalle C
Department of Rheumatology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F.
Neuropediatrics. 1996 Feb;27(1):42-4. doi: 10.1055/s-2007-973746.
We describe a 13-year-old female patient with systemic lupus erythematosus (SLE) who presented with acute transverse myelitis (ATM) in the course of SLE. IgG and IgM anticardiolipin antibodies (aCL) were positive at moderate titers. Magnetic resonance imaging (MRI) of the thoracic spine demonstrated decreased signal intensity and diffuse edema of the spinal cord from T2 to T6 on T1-weighted images. Dramatic clinical improvement of the neurologic impairment was noted a few days after high dose intravenous (IV) methylprednisolone (MP) and cyclophosphamide (Cy). Herein we further emphasize the benefit of IV MP and Cy in ATM and the relationship between ATM and antiphospholipid antibodies (aPLA) in SLE.
我们描述了一名13岁患有系统性红斑狼疮（SLE）的女性患者，她在SLE病程中出现了急性横贯性脊髓炎（ATM）。IgG和IgM抗心磷脂抗体（aCL）呈中度滴度阳性。胸椎磁共振成像（MRI）在T1加权图像上显示脊髓从T2至T6信号强度降低及弥漫性水肿。在大剂量静脉注射甲基强的松龙（MP）和环磷酰胺（Cy）几天后，神经功能障碍出现显著临床改善。在此我们进一步强调静脉注射MP和Cy对ATM的益处以及SLE中ATM与抗磷脂抗体（aPLA）之间的关系。
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