Wang J C, Kim D S, Goldberg M
Department of Medicine, Brookdale Hospital Medical Center, Brooklyn, NY 11212, USA.
Acta Haematol. 1996;96(1):45-9. doi: 10.1159/000203714.
Ki-1 anaplastic large cell lymphoma (Ki-1 ALCL) is a recently recognized entity. Primary presentation in the bone is very rare. Very few cases of primary bone presentation have been reported. All previous reported patients were children and young adults, usually with multiple bone involvement. We report a case of a 60-year old man who presented with extensive mixed blastic and lytic lesions in one tibia, simulating osteogenic sarcoma radiographically, with regional lymphadenopathy. Further studies showed this tumor to be a B cell Ki-1 ALCL. Tumor cells stained positive for Ki-1 antigen (CD30), leukocyte common antigen (CD45), vimentin, and L26 (CD20), negative for cytokeratin, S100, Leu M1 (CD15). The patient was treated with combination chemotherapy and local radiation, with an excellent initial response.
Ki-1间变性大细胞淋巴瘤（Ki-1 ALCL）是一种最近才被认识的疾病实体。原发性骨表现非常罕见。此前报道的原发性骨表现病例极少。所有先前报道的患者均为儿童和青年，通常有多发性骨受累。我们报告一例60岁男性，其一侧胫骨出现广泛的混合性成骨和溶骨性病变，影像学表现类似骨肉瘤，并伴有区域淋巴结肿大。进一步研究显示该肿瘤为B细胞Ki-1 ALCL。肿瘤细胞Ki-1抗原（CD30）、白细胞共同抗原（CD45）、波形蛋白和L26（CD20）染色呈阳性，细胞角蛋白、S100、Leu M1（CD15）染色呈阴性。该患者接受了联合化疗和局部放疗，初始反应良好。
