Eckardt V F, Dodt O, Kanzler G, Bernhard G
Gastroenterologisches Institut Wiesbaden, Germany.
Am J Gastroenterol. 1996 Apr;91(4):686-9.
Although no generally effective treatment for proctalgia fugax is known, inhalation of salbutamol has been reported to shorten pain attacks in isolated cases.
We conducted a randomized, double-blind, placebo-controlled, crossover trial of inhaled salbutamol in 18 patients with proctalgia fugax. The clinical effect was evaluated by recording the duration of severe pain and discomfort during acute attacks. In addition, anorectal motility recordings were analyzed for possible changes in anal resting tone, sphincter relaxation during rectal distension and in rectal compliance prior to and following administration of the two test substances.
Sixteen patients completed all investigations. Compared to placebo, salbutamol inhalation shortened the duration of severe pain (p = 0.019). The effect was most marked in patients having prolonged attacks. In the asymptomatic state, neither salbutamol nor placebo led to a significant change in anal resting pressure, anal relaxation during rectal distension, or rectal compliance. Salbutamol also did not alter the threshold for rectal sensation.
Salbutamol inhalation shortens attacks of severe pain in patients with proctalgia fugax. The mechanism of this effect remains unexplained.
虽然目前尚无治疗直肠一过性疼痛的普遍有效的方法，但有报道称，沙丁胺醇吸入可缩短个别病例的疼痛发作时间。
我们对18例直肠一过性疼痛患者进行了一项吸入沙丁胺醇的随机、双盲、安慰剂对照交叉试验。通过记录急性发作期间剧痛和不适的持续时间来评估临床疗效。此外，还对肛肠动力记录进行了分析，以观察在给予两种受试药物前后，肛门静息张力、直肠扩张时括约肌松弛情况以及直肠顺应性是否可能发生变化。
16例患者完成了所有调查。与安慰剂相比，吸入沙丁胺醇缩短了剧痛的持续时间（p = 0.019）。这种效果在发作时间延长的患者中最为明显。在无症状状态下，沙丁胺醇和安慰剂均未导致肛门静息压力、直肠扩张时肛门松弛或直肠顺应性发生显著变化。沙丁胺醇也未改变直肠感觉阈值。
吸入沙丁胺醇可缩短直肠一过性疼痛患者的剧痛发作时间。这种作用机制尚不清楚。
