Toyoda H, Nakano S, Kumada T, Takeda I, Sugiyama K, Osada T, Kiriyama S
Department of Gastroenterology, Ogaki Municipal Hospital, Japan.
Am J Gastroenterol. 1996 Apr;91(4):743-7.
A randomized, controlled trial was performed to study the effect of the period of daily administration of interferon therapy in patients with chronic hepatitis C.
Sixty-three patients were administered a total dose of 480 MU of natural alpha-interferon, 6 MU each day. In 32 cases, interferon was given daily for 2 wk, followed by intermittent administration (three times a week) for 22 wk. The other 31 patients received daily administration for 8 wk, followed by intermittent administration (twice a week) for 12 wk. The responses were based on the normalization of ALT and the clearance of hepatitis C virus.
Although ALT normalized in 37 patients during the administration of interferon, it relapsed after the end of interferon therapy in 20 patients. The other 17 patients achieved sustained normalization of ALT and clearance of hepatitis C virus RNA. Responses did not differ according to the administration period of interferon.
Prolonged daily administration did not improve the responses to interferon therapy when the total dose was the same.
开展一项随机对照试验，以研究慢性丙型肝炎患者每日给予干扰素治疗的疗程对疗效的影响。
63例患者接受总量为480MU的天然α干扰素治疗，每日剂量为6MU。32例患者每日给予干扰素治疗2周，随后每周3次间歇给药22周。另外31例患者每日给药8周，随后每周2次间歇给药12周。疗效基于ALT恢复正常和丙型肝炎病毒清除情况来判定。
尽管37例患者在干扰素治疗期间ALT恢复正常，但20例患者在干扰素治疗结束后ALT复发。另外17例患者实现了ALT持续正常及丙型肝炎病毒RNA清除。疗效不因干扰素给药疗程的不同而有差异。
当总剂量相同时，延长每日给药时间并不能改善干扰素治疗的疗效。
