Rossing M A, Stanford J L, Weiss N S, Habel L A
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA., USA.
Am J Epidemiol. 1996 Jul 15;144(2):161-4. doi: 10.1093/oxfordjournals.aje.a008903.
The authors used data from a population-based, case-control study of breast cancer conducted among women residing in King County, Washington State, who were 50-64 years of age in 1988-1990, to examine the relation of oral contraceptive use to the risk of breast cancer. There were no clear differences between cases and controls with respect to the total duration of oral contraceptive use, time since last use, or age at first or last use. While a small increase in risk was noted in women who had first used oral contraceptives within 20 years of the interview reference date, within that period there was no trend in risk observed with decreasing amounts of time since the last use of these agents. Overall, this study supports the absence of any strong association between oral contraceptive use and breast cancer risk during middle age in the cohort of women who first used these drugs.
作者利用了一项基于人群的病例对照研究数据，该研究在华盛顿州金县居住的50 - 64岁女性中开展，这些女性在1988 - 1990年期间参与研究，目的是检验口服避孕药的使用与患乳腺癌风险之间的关系。在口服避孕药的总使用时长、最后一次使用后的时间，或首次或最后一次使用时的年龄方面，病例组和对照组之间没有明显差异。虽然在访谈参考日期前20年内首次使用口服避孕药的女性中，风险有小幅增加，但在该时间段内，未观察到随着这些药物最后一次使用后时间的减少，风险有任何趋势变化。总体而言，本研究支持在首次使用这些药物的中年女性队列中，口服避孕药的使用与乳腺癌风险之间不存在任何强关联。
