Brydon C W, Basler M, Kerr W J
Department of Anaesthesia, Victoria Infirmary, Glasgow.
Anaesthesia. 1995 Nov;50(11):998-1000. doi: 10.1111/j.1365-2044.1995.tb05940.x.
We studied the effect of the addition of hyaluronidase to a mixture of lignocaine 2% and bupivacaine 0.75% for peribulbar anaesthesia in 60 patients presenting for elective intra-ocular surgery. Using a randomised, double-blind design, patients were allocated to one of three groups: no hyaluronidase (group A) (n = 20); hyaluronidase 50 iu.ml-1 (group B) (n = 20); hyaluronidase 150 iu.ml-1 (group C) (n = 20). The speed of onset of the block, the presence of akinesia, analgesia and the need for supplementary injections were assessed. The addition of 150 iu.ml-1 of hyaluronidase resulted in a mean (SEM) time to akinesia of 9.2 (0.9) min compared to 10.9 (0.9) min in the control group and 10.7 (1.1) min in those receiving the lower dose. Fewer patients in group C required a further injection (20%) than those in groups A (40%) or B (45%). None of the findings were statistically significant. Hyaluronidase was not associated with any complications.
我们研究了在60例择期眼内手术患者中，向2%利多卡因和0.75%布比卡因混合液中添加透明质酸酶用于球周麻醉的效果。采用随机双盲设计，将患者分为三组之一：不添加透明质酸酶（A组）（n = 20）；透明质酸酶50 iu.ml-1（B组）（n = 20）；透明质酸酶150 iu.ml-1（C组）（n = 20）。评估了阻滞起效速度、眼球运动不能、镇痛情况以及补充注射的必要性。添加150 iu.ml-1透明质酸酶后，平均（标准误）达到眼球运动不能的时间为9.2（0.9）分钟，而对照组为10.9（0.9）分钟，接受较低剂量的组为10.7（1.1）分钟。C组需要进一步注射的患者（20%）少于A组（40%）或B组（45%）。所有结果均无统计学意义。透明质酸酶未引起任何并发症。
