Saika T, Tsushima T, Nasu Y, Akebi N, Ohmori H
Dept. of Urology, Okayama University Medical School, Japan.
Gan To Kagaku Ryoho. 1996 Jun;23(7):905-9.
To establish a method for reasonable clinical use of adriamycin (ADM) and pirarubicin (THP) in the intravesical chemotherapy for superficial bladder cancer, intracellular concentrations of these drugs were examined in culture cell lines (T-24, T-24/ADM and FHS736b1) with variable durations of contamination. The intracellular concentration of THP showed a plateau at 15-30 min. contamination in T-24, and in T-24/ADM, and showed the time dependence of contamination in FHS736b1, human normal bladder mucosa cell line. The intracellular concentration of ADM showed the time dependence of contamination in T-24, T-24/ADM and FHS736b1. And these concentrations of THP were 20 times higher than those of ADM. In conclusion, it seems better that THP was retained for 5-15 min. in the bladder in the intravesical chemotherapy, from the point of view of drug efficacy and preventing side effects. And it seems good that ADM was retained for more than 30 min. in the case with drug sensitive tumors.
为建立一种在浅表性膀胱癌膀胱内化疗中合理临床使用阿霉素（ADM）和吡柔比星（THP）的方法，在不同污染时长的培养细胞系（T-24、T-24/ADM和FHS736b1）中检测了这些药物的细胞内浓度。THP在T-24和T-24/ADM中污染15 - 30分钟时细胞内浓度出现平台期，而在人正常膀胱黏膜细胞系FHS736b1中呈现污染时间依赖性。ADM在T-24、T-24/ADM和FHS736b1中均呈现污染时间依赖性。并且THP的这些浓度比ADM高20倍。总之，从药物疗效和预防副作用的角度来看，在膀胱内化疗中THP在膀胱内保留5 - 15分钟似乎更好。而对于药物敏感肿瘤，ADM保留超过30分钟似乎较好。
