Muros M, Rodríguez-Ferrer C
Servicio de Laboratorio, Hospital Nuestra Señora de Candelaria, Tenerife, Spain.
Atherosclerosis. 1996 Mar;121(1):13-21. doi: 10.1016/0021-9150(95)06643-8.
The apolipoprotein E (apo E) polymorphism in a Spanish working population of Tenerife (Canary Islands, Spain) was analyzed. The distribution of apo E alleles (epsilon 3, 0.850; epsilon 2, 0.075; epsilon 4, 0.075) and phenotypes (E3/3, 72.6%; E3/4, 13%; E3/2, 11.5%; E4/4, 0.8%; E2/2, 1.5%; E4/2, 0.5%) was significantly different from those of a combined Caucasian population owing to a lower frequency of apo E4. We have also investigated the effect of apo E polymorphism on serum levels of cholesterol, LDL-cholesterol, HDL-cholesterol, Lp(a) and apolipoproteins A-I, B and E. The average effect of E4 (in whole sample and men only, respectively) was to raise serum levels of total cholesterol (by 4.1 mg/dl and 8.3 mg/dl), LDL-cholesterol (by 6.5 mg/dl and 9 mg/dl), and apo B (5.3 mg/dl and 4.5 mg/dl). The average effect of E2 was to lower serum levels of total cholesterol (by 14.8 mg/dl mg/dl and 8.3 mg/dl), LDL-cholesterol (by 20.2 mg/dl and 15.5 mg/dl) and apo B (11.5 mg/dl and 6.5 mg/dl), and to raise apo E (1.14 mg/dl and 3.4 mg/dl and 3.4 mg/dl). We found significantly higher serum triglyceride levels in individuals carrying E4, but no differences were found in serum HDL-cholesterol, apo A-I or Lp(a) by alleles. Data confirm previous reports about an underexpression of apo E4 in societies living in Southern Europe, and its repercussion in a more beneficial lipid profile and relatively low cardiovascular mortality rate in the Mediterranean region.
对西班牙特内里费岛（加那利群岛，西班牙）一个工作人群的载脂蛋白E（apo E）多态性进行了分析。apo E等位基因（ε3，0.850；ε2，0.075；ε4，0.075）和表型（E3/3，72.6%；E3/4，13%；E3/2，11.5%；E4/4，0.8%；E2/2，1.5%；E4/2，0.5%）的分布与混合白种人群显著不同，原因是apo E4的频率较低。我们还研究了apo E多态性对血清胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、脂蛋白(a)以及载脂蛋白A-I、B和E水平的影响。E4（分别在整个样本和仅男性样本中）的平均作用是提高血清总胆固醇水平（分别提高4.1mg/dl和8.3mg/dl）、低密度脂蛋白胆固醇水平（分别提高6.5mg/dl和9mg/dl）以及载脂蛋白B水平（分别提高5.3mg/dl和4.5mg/dl）。E2的平均作用是降低血清总胆固醇水平（分别降低14.8mg/dl和8.3mg/dl）、低密度脂蛋白胆固醇水平（分别降低20.2mg/dl和15.5mg/dl）以及载脂蛋白B水平（分别降低11.5mg/dl和6.5mg/dl），并提高载脂蛋白E水平（分别提高1.14mg/dl和3.4mg/dl以及3.4mg/dl）。我们发现携带E4的个体血清甘油三酯水平显著更高，但按等位基因分析，血清高密度脂蛋白胆固醇、载脂蛋白A-I或脂蛋白(a)没有差异。数据证实了先前关于apo E4在生活于南欧的社会中表达不足及其对地中海地区更有益的血脂谱和相对较低心血管死亡率影响的报道。
