Mapping the homolog of the human Rb1 gene to chromosome 14 of higher primates.

作者信息

Verma R S, Ramesh K H, Samonte R V, Conte R A

机构信息

Division of Genetics, Long Island College Hospital, Hicks Street at Atlantic Avenue, SUNY Health Science Center, Brooklyn, New York, 11201, USA.

出版信息

Mamm Genome. 1996 Aug;7(8):591-2. doi: 10.1007/s003359900175.

The Rb1 gene has been implicated with retinoblastoma and is located on human Chromosome (Chr) 13q14.2. A unique sequence human Rb1 cosmid DNA probe has been used to localize this region on apes' Chr 14 by the FISH technique. The conservation of the Rb1 gene in higher primates at the corresponding equivalent chromosome locus (14q14) of the human may serve as a phylogenetic marker to further trace the evolutionary pathway of human descent.