Pessione F, Gerchstein J L, Rueff B
Alcohol Unit STAMA, Hôpital Beaujon, Clichy, France.
Alcohol Alcohol. 1995 Nov;30(6):749-54.
The aim of this study was to identify the risk factors of alcohol-related peripheral neuropathies. A case-control study was performed to compare two groups of alcoholic patients, one with peripheral neuropathy and the other without, but with alcohol-related cirrhosis, pancreatitis or cardiomyopathy. Ninety patients were recruited in four in-patient units of a French hospital: 32 patients had a peripheral neuropathy and 58 patients did not. Univariate analysis showed no differences between the two groups for sex, age, body mass index and duration of the alcoholic disease. Peripheral neuropathies were associated with a higher frequency of parental history of alcoholism, severity of alcohol dependence, heavier alcohol consumption and more alcohol-related somatic diseases. Multivariate analysis showed a strong relationship between a parental history of alcoholism and the presence of a neuropathy, when the severity of the alcoholic disease was taken into account (adjusted OR = 6.8, IC95% [2.2-21.6], P < 0.001). The hypothesis that neuropathy may be a marker of an inherited susceptibility to alcoholism is discussed.
本研究的目的是确定酒精相关性周围神经病的危险因素。进行了一项病例对照研究，以比较两组酒精性患者，一组患有周围神经病，另一组未患，但患有酒精性肝硬化、胰腺炎或心肌病。在一家法国医院的四个住院科室招募了90名患者：32名患者患有周围神经病，58名患者未患。单因素分析显示，两组在性别、年龄、体重指数和酒精性疾病病程方面无差异。周围神经病与酒精中毒家族史的频率较高、酒精依赖的严重程度、饮酒量较大以及更多的酒精相关性躯体疾病有关。多因素分析显示，当考虑酒精性疾病的严重程度时，酒精中毒家族史与神经病的存在之间存在密切关系（校正比值比=6.8，95%置信区间[2.2-21.6]，P<0.001）。本文讨论了神经病可能是酒精中毒遗传易感性标志物的假说。
