Swearer J M, O'Donnell B F, Ingram S M, Drachman D A
Department of Neurology, University of Massachusetts Medical Center, Worchester 01655, USA.
J Geriatr Psychiatry Neurol. 1996 Jan;9(1):22-5. doi: 10.1177/089198879600900104.
The clinical course of early-onset, dominantly inherited, familial Alzheimer's disease (FAD) was contrasted with late-onset, sporadic Alzheimer's disease (AD). Eight FAD and 23 sporadic AD patients were followed over a mean of 63 months from estimated disease onset. The two groups did not differ notably in duration of symptoms from onset, global disease severity, or degree of cognitive deficits on initial evaluation. The Kaplan-Meier lifetable method was used to assess time from estimated disease onset to dependence in self-care, institutionalization, and death. A greater percentage of FAD patients became dependent in self-care and died earlier than did sporadic AD patients. The lifetable results suggest that FAD may have a more rapid course than dose late-onset sporadic AD.
早发性、显性遗传的家族性阿尔茨海默病（FAD）的临床病程与晚发性散发性阿尔茨海默病（AD）形成对比。从估计的疾病发病起，对8名FAD患者和23名散发性AD患者进行了平均63个月的随访。两组在症状出现后的持续时间、整体疾病严重程度或初次评估时的认知缺陷程度方面没有显著差异。采用Kaplan-Meier生存表法评估从估计的疾病发病到生活自理依赖、入住机构和死亡的时间。与散发性AD患者相比，更大比例的FAD患者出现生活自理依赖且死亡更早。生存表结果表明，FAD的病程可能比晚发性散发性AD更快。
