拮抗人类2型辅助性T细胞的分化和功能。
Antagonizing the differentiation and functions of human T helper type 2 cells.
作者信息
de Vries J E, Carballido J M, Sornasse T, Yssel H
机构信息
Human Immunology Department, Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.
出版信息
Curr Opin Immunol. 1995 Dec;7(6):771-8. doi: 10.1016/0952-7915(95)80046-8.
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.
来自特应性患者的变应原特异性T细胞通常属于辅助性T细胞2型亚群。这些细胞产生的白细胞介素-4和白细胞介素-13可诱导B细胞合成免疫球蛋白E，并在由免疫球蛋白E介导的过敏性疾病中起主要作用。我们对辅助性T细胞2型细胞的分化和诱导免疫球蛋白E活性的最新认识进展表明，靶向变应原特异性T细胞可能为干预过敏提供一种新方法。
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