Dazert S, Muss W H
Department of Otolaryngology-Head and Neck Surgery, University of Würzburg, Germany.
Eur Arch Otorhinolaryngol. 1995;252(6):332-5. doi: 10.1007/BF00178271.
Osteoplastic frontal sinus surgery in combination with sinus obliteration can be performed for various indications, including chronic sinusitis, frontal sinus trauma and removal of osteomas. In an experimental study using cats, the mucous lining of the frontal sinus was removed, the nasofrontal duct sealed with semifluid ionomer cement and the cavity filled with Ionogran, a solid and porous bone substitute based on ionomer cement. Histological investigations up to 1 year after surgery showed increasing sinus obliteration by regenerating bone, starting from the sinus wall, and formation of connective tissue between the cement grains. There was no evidence for mucosal regeneration. Electron microscopic examination of the interface between the cement and connective tissue revealed mesenchymal cells, collagen fibers and areas of mineralization in close contact with the implant material. Newly formed connective tissue matrix in intimate contact with the cement was a good indication for biocompatibility of the material and is a possible explanation for the implant's solid adhesion to bone. The present findings indicate that Ionogran is a suitable alloplastic material for experimental frontal sinus obliteration in cats.
骨成形性额窦手术联合鼻窦闭塞术可用于多种适应症，包括慢性鼻窦炎、额窦创伤和骨瘤切除。在一项以猫为对象的实验研究中，去除了额窦的黏膜衬里，用半流体离聚物粘固剂封闭鼻额管，并用Ionogran填充腔隙，Ionogran是一种基于离聚物粘固剂的固体多孔骨替代物。术后长达1年的组织学研究显示，从窦壁开始，再生骨使鼻窦闭塞逐渐增加，并且在粘固剂颗粒之间形成了结缔组织。没有黏膜再生的证据。对粘固剂与结缔组织之间界面的电子显微镜检查显示，间充质细胞、胶原纤维和矿化区域与植入材料紧密接触。与粘固剂紧密接触的新形成的结缔组织基质是该材料生物相容性的良好指标，也是植入物与骨牢固粘连的可能解释。目前的研究结果表明，Ionogran是用于猫实验性额窦闭塞的合适的同种异体材料。
