Dazert S
Universitäts-HNO-Klinik Würzburg.
HNO. 1994 Dec;42(12):734-7.
Ionogran is both a solid and porous bone substitute. It is based on ionomer cement, a material obtained by a neutralization reaction between a glass powder and a polymaleic acid. This material has already been used for reconstruction of large bony defects following tumor surgery. In an experimental study, the maxillary sinuses in 12 rabbits were obliterated using the ionomer-based microimplant. This granulate was placed on the intact mucosa or immediately on bone after removal of the mucoperiostal lining. After its application to intact sinus mucosa no bone regeneration was detected. In contrast, after application to exposed bone osteoneogenesis was observed 28 days later, starting from the bony sinus wall. After periods of 56-84 days, a continued increase in new bone was seen inside the obliterated cavity. These results indicate that Ionogran is suitable for obliteration of the paranasal sinuses after complete removal of the mucosal lining.
Ionogran是一种固体且多孔的骨替代物。它基于离聚物骨水泥，这种材料是通过玻璃粉与聚马来酸之间的中和反应获得的。该材料已用于肿瘤手术后大的骨缺损重建。在一项实验研究中，使用基于离聚物的微植入物闭塞了12只兔子的上颌窦。这种颗粒置于完整的黏膜上，或在去除黏膜骨膜内衬后立即置于骨上。将其应用于完整的鼻窦黏膜后未检测到骨再生。相反，应用于暴露的骨后，28天后观察到从骨窦壁开始有骨生成。在56 - 84天之后，在闭塞腔内可见新骨持续增加。这些结果表明，Ionogran适用于在完全去除黏膜内衬后闭塞鼻窦。
