Barone P, Sciacca A, Lupo F, Leonardi S, Musumeci S
Dpt. of Paediatrics, University of Catania.
Ann Ig. 1995 Jul-Aug;7(4):251-5.
Several reports have clearly demonstrated that intradermal way of administration of hepatitis B vaccine represent a valid alternative to the intramuscular route, producing an high percentage of seroconversion. The characteristics of the intradermal way, short time of immunization and lower cost, have induced us to conduct a clinical trial among 116 healthcare workers in a hospital setting, which represent an high risk group especially at their first admission to the hospital. 99 selected participants (average age 22 years, range 17-27) received, after screening for HBV markers, 5 mcg of vaccine intradermally on the volar surface of the forearm, according to the schedule 0, 15, 30 and 45 days. Serum samples were collected after one month from the last inoculation of vaccine. The percentage of seroconversions obtained was significantly high (93.9%) confirming that intradermal vaccination with hepatitis B vaccine may be appropriate in providing a rapid protection for certain population subgroups.
多项报告已明确表明，皮内注射乙肝疫苗是肌肉注射途径的一种有效替代方法，能产生较高的血清转化率。皮内注射方式具有免疫时间短和成本较低的特点，这促使我们在一家医院环境中的116名医护人员中开展了一项临床试验，这些医护人员是高危人群，尤其是在他们首次入院时。99名选定的参与者（平均年龄22岁，范围17 - 27岁）在进行乙肝病毒标志物筛查后，按照0、15、30和45天的时间表，在前臂掌面皮内注射5微克疫苗。在最后一次接种疫苗一个月后采集血清样本。获得的血清转化率非常高（93.9%），证实皮内接种乙肝疫苗可能适合为某些人群亚组提供快速保护。
