Gonzalez I G, Martin Luquero M, Marcos Martinez L, Gargallo Fernandez M A
Servicio de Medicina Interna, Hospital Pío del Río Hortega, Valladolid.
An Med Interna. 1995 Dec;12(12):593-6.
We studied in two groups of epileptic patients the thyroid alterations induced by anticonvulsant therapy (AC). Group I (28 cases): T4t and TSH were measured before and after 3 and 6 months on treatment with AC. Group II (75 cases on treatment): thyroid hormones were measured only once. In cases with low value of T4t or high TSH a TRH test and FT4 determination were performed. In group I two cases with low T4t were found after six months on treatment (7%), one of them with low FT4 and both with normal TSH. In group II we found 6 cases (7.8%) with low T4t and FT4, two of them with high TSH. It was not possible argue against factor and the low incidence reported argue against rutinary screening. Anycase, this screening will never be performed before the lag time observed (6 months).
我们在两组癫痫患者中研究了抗惊厥治疗（AC）引起的甲状腺改变。第一组（28例）：在接受AC治疗3个月和6个月前后测量T4t和TSH。第二组（75例正在接受治疗）：仅测量一次甲状腺激素。对于T4t值低或TSH高的病例，进行促甲状腺激素释放激素（TRH）试验和游离甲状腺素（FT4）测定。在第一组中，治疗6个月后发现2例T4t低的病例（7%），其中1例FT4低，两者TSH均正常。在第二组中，我们发现6例（7.8%）T4t和FT4低，其中2例TSH高。无法反驳该因素，且所报道的低发病率反对常规筛查。无论如何，在观察到的延迟时间（6个月）之前绝不会进行这种筛查。
