De Frutos Arribas J F, Del Río Fernández M C, Bellido Casado J, Carretero Sastre J L, Puyo Gil M
Sección de Neumologia, Hospital del Río Hortega, Valladolid.
An Med Interna. 1996 Mar;13(3):118-21.
We studied 14 patients with bronchioalveolar carcinoma during the last 14 years. In all cases we evaluated the clinical history, the radiologic presentation, and the diagnostic procedures. The mean age of presentation of the illness was 58.5 years. The incidence of smokers was 35%. The time interval from clinical manifestations to diagnosis was 3,3 months. The most frequent symptoms were cough (57%) and dyspnea (43%). The 21% of the cases were asymptomatic. Two patients (14%) had copious amounts of sputum (bronchorrhea). The most revealing radiologic pattern was of alveolar type (43%), followed by multiple pulmonary nodules (29%) and solitary pulmonary nodule pattern (21%). The diagnosis was based in specimen obtained from transbronchial biopsy, bronchoalveolar lavage, transthoracic aspiration biopsy, thoracotomy, or during the necropsy study. Transbronchial biopsy was a sensitive diagnostic method. The 64% of patients were in a extent disease when the diagnosis was established.
在过去14年里，我们对14例细支气管肺泡癌患者进行了研究。在所有病例中，我们评估了临床病史、放射学表现和诊断程序。发病的平均年龄为58.5岁。吸烟者的发病率为35%。从临床表现到诊断的时间间隔为3.3个月。最常见的症状是咳嗽（57%）和呼吸困难（43%）。21%的病例无症状。两名患者（14%）有大量痰液（支气管分泌过多）。最具特征性的放射学表现为肺泡型（43%），其次是多发肺结节（29%）和孤立肺结节型（21%）。诊断基于经支气管活检、支气管肺泡灌洗、经胸穿刺活检、开胸手术或尸检研究获得的标本。经支气管活检是一种敏感的诊断方法。64%的患者在确诊时处于疾病进展期。
