Poletti V, Romagna M, Allen K A, Gasponi A, Spiga L
Service of Bronchology, Bellaria Hospital, Bologna, Italy.
Acta Cytol. 1995 May-Jun;39(3):472-7.
We report our experience with bronchoalveolar lavage (BAL) and its value in the diagnosis of malignant lung infiltrates. A total of 162 patients with biopsy- or autopsy-proven cancer had an analysis of BAL fluid performed. Cytologic examination showed malignant cells in 123 (76%) patients. The diagnostic accuracy varied depending on the neoplastic nature and growth pattern of the disease. BAL disclosed cancer cells in 93% of 44 bronchioloalveolar carcinomas. Carcinomatous lymphangitis due to metastatic cancer was diagnosed in 83% of 69 cases. Hematogenous metastases (with sharply circumscribed nodules on chest radiography) were diagnosed in 45% of 22 such cases. We recognized 67% of 15 non-Hodgkin's lymphomas and 3 of 9 cases of Hodgkin's disease with pulmonary involvement. Immunocytochemistry using monoclonal and/or polyclonal antibodies was of value in the identification and classification of cells in non-Hodgkin's lymphoma.
我们报告了支气管肺泡灌洗（BAL）的经验及其在诊断肺部恶性浸润中的价值。共有162例经活检或尸检证实患有癌症的患者接受了BAL液分析。细胞学检查显示，123例（76%）患者的BAL液中有恶性细胞。诊断准确性因疾病的肿瘤性质和生长模式而异。BAL在44例细支气管肺泡癌中的93%发现了癌细胞。69例因转移性癌导致的癌性淋巴管炎中，83%得到诊断。22例血行转移（胸部X线片上有边界清晰的结节）患者中，45%得到诊断。我们识别出15例非霍奇金淋巴瘤中的67%以及9例累及肺部的霍奇金病中的3例。使用单克隆和/或多克隆抗体的免疫细胞化学在非霍奇金淋巴瘤细胞的识别和分类中具有价值。
