Luo D F, Maclaren N K, Huang H S, Muir A, She J X
Department of Pathology and Laboratory Medicine, University of Florida, Gainesville 32610, USA.
Autoimmunity. 1995;21(2):143-7. doi: 10.3109/08916939508993363.
We have performed intrafamilial and case-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.
我们进行了家族内和病例对照关联研究，以检验先前报道的位于2号染色体q31 - q33区域（IDDM7）的D2S152与1型糖尿病易感基因之间的连锁不平衡。在我们选取的47个佛罗里达患病同胞对家庭子集中观察到显著的连锁不平衡（p < 0.02），但在其他57个美国家庭中未观察到。在从佛罗里达确定的270名无亲缘关系的糖尿病患者和370名正常对照的白种人数据集中，以及在90名患者和169名正常对照的中国数据集中，我们通过病例对照研究未能检测到IDDM与D2S152之间存在任何显著关联。我们的结果表明，IDDM7与D2S152之间的连锁不平衡必定非常松散。
