Zamani M, Pociot F, Raeymaekers P, Nerup J, Cassiman J J
Center for Human Genetics, University of Leuven, Belgium.
Hum Genet. 1996 Oct;98(4):491-6. doi: 10.1007/s004390050245.
Affected sib pair and linkage disequilibrium analysis, intrafamilial and case-control association studies were performed on 81 Danish multiplex insulin-dependent diabetes mellitus (IDDM) families (382 individuals) and 82 healthy Danish controls. The results confirm the linkage of D15S107 to IDDM in these Danish IDDM families (P = 0.010). When these data are combined with those of previous studies, an even stronger case for linkage can be made (P = 0.0005). Our analyses show that the D15S107*130 allele provides increased susceptibility (P = 0.02, relative risk = 3.55) and that the D15S107 locus contributes up to 16% of the familial clustering of IDDM. The analysis of affected sib pairs suggests that HLA and D15S107 may possibly act independently of each other. Taken together with our previous findings, our results suggest that three causes of susceptibilities can be discerned in the IDDM patient population: (1) a major susceptibility caused by the HLA-DRB1 alleles; (2) a minor susceptibility caused by the joint action of HLA and other non-HLA gene(s); and (3) a minor susceptibility caused by non-HLA gene(s).
对81个丹麦多成员胰岛素依赖型糖尿病（IDDM）家庭（382人）和82名健康丹麦对照者进行了受累同胞对及连锁不平衡分析、家族内及病例对照关联研究。结果证实了在这些丹麦IDDM家庭中D15S107与IDDM的连锁关系（P = 0.010）。当将这些数据与先前研究的数据相结合时，连锁的证据更强（P = 0.0005）。我们的分析表明，D15S107*130等位基因增加了易感性（P = 0.02，相对风险 = 3.55），且D15S107位点对IDDM家族聚集性的贡献率高达16%。对受累同胞对的分析表明，HLA和D15S107可能相互独立起作用。结合我们之前的研究结果，我们的结果表明，在IDDM患者群体中可识别出三种易感性原因：（1）由HLA-DRB1等位基因引起的主要易感性；（2）由HLA和其他非HLA基因共同作用引起的次要易感性；（3）由非HLA基因引起的次要易感性。
