Asaka T, Takizawa Y, Kariya T, Nitta E, Yasuda T, Fujita M, Sawasaki S, Naiki Y, Nakatani N, Doushita T, Miura T, Ueda F, Takamori M, Matsushima A
Department of Medicine and Pediatrics, Nanao National Hospital.
Intern Med. 1996 Feb;35(2):162-5. doi: 10.2169/internalmedicine.35.162.
A 74-year-old woman was noted to have a mass lesion near the right elbow joint during medication for pulmonary tuberculosis. After discontinuation of medication, the mass gradually became enlarged with swelling and tenderness of the joint. Radiological evaluation disclosed tenosynovitis with an encapsulated abscess. Microscopic examination and culture of an aspiration biopsy specimen from the abscess showed no microorganisms. However, DNA extracted from the specimen contained mycobacterium tuberculosis DNA, permitting a diagnosis of tuberculous tenosynovitis. Mycobacterium is not always detected in biopsy specimens of tuberculous arthritis and tenosynovitis. In such cases, genetic diagnosis may be of great use.
一名74岁女性在接受肺结核治疗期间,被发现右肘关节附近有一肿块病变。停药后,肿块逐渐增大,关节出现肿胀和压痛。影像学评估显示为腱鞘炎伴包裹性脓肿。对脓肿穿刺活检标本进行显微镜检查和培养未发现微生物。然而,从标本中提取的DNA含有结核分枝杆菌DNA,从而确诊为结核性腱鞘炎。在结核性关节炎和腱鞘炎的活检标本中并不总是能检测到结核分枝杆菌。在这种情况下,基因诊断可能非常有用。