Cornwell C A, Chang J W, Cole B, Fukada Y, Gianulli T, Rathbone E A, McFarlane H, McGaugh J L
Department of Psychology, Syracuse University, NY 13244-2340, USA.
Brain Res. 1996 Mar 4;711(1-2):26-33. doi: 10.1016/0006-8993(95)01327-x.
Control cagemates of rats treated with the norepinephrine (NE) neurotoxin DSP-4, showed normal olfactory learning as infants, but abnormal aversion to home-cage odors as juveniles. Neither age nor social housing conditions influenced the odor preferences of DSP-4-treated rats: they showed tolerance or attraction to familiar odors at both developmental stages. Controls, but not DSP-4-treated juveniles, housed in mixed treatment groups, showed elevated concentrations of a serotonin metabolite and reduced NE concentrations in the hippocampus, suggesting that this social situation was particularly stressful for the controls. DSP-4-treated juveniles, but not infants, produced odors that were discriminable from controls'. Thus, conflicting olfactory signals in the home-cages of mixed juvenile groups may have led to the development of stress in controls. NE depletion appeared to lessen social stress effects in their DSP-4-treated cagemates. These findings support other data suggesting that NE modulates the biobehavioral effects of the social environment.
用去甲肾上腺素（NE）神经毒素DSP-4处理的大鼠的对照同笼伙伴，在幼年时嗅觉学习正常，但在青少年期对笼内气味表现出异常厌恶。年龄和社会饲养条件均未影响DSP-4处理大鼠的气味偏好：它们在两个发育阶段都对熟悉的气味表现出耐受或吸引。饲养在混合处理组中的对照组（而非DSP-4处理的青少年大鼠），海马体中血清素代谢物浓度升高，NE浓度降低，这表明这种社会环境对对照组来说特别有压力。DSP-4处理的青少年大鼠（而非幼鼠）产生的气味与对照组的不同。因此，混合青少年组笼内相互冲突的嗅觉信号可能导致了对照组压力的产生。NE耗竭似乎减轻了其DSP-4处理的同笼伙伴的社会压力影响。这些发现支持了其他数据，表明NE调节社会环境的生物行为效应。
