局灶性重症肌无力作为犬胸腺肿瘤的副肿瘤综合征：胸腺切除术后病情改善

Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy.

作者信息

Lainesse M F, Taylor S M, Myers S L, Haines D, Fowler J D

机构信息

Department of Veterinary Internal Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.

出版信息

J Am Anim Hosp Assoc. 1996 Mar-Apr;32(2):111-7. doi: 10.5326/15473317-32-2-111.

DOI:10.5326/15473317-32-2-111

PMID:8680916

Abstract

A 10-year-old, neutered male cocker spaniel-cross experienced regurgitation, dry retching, and weight loss. A large, mediastinal mass and dilatation of the esophagus were seen on thoracic radiographs. Cytological, histopathological, immunohistochemical, and serological findings were consistent with a lymphoepithelial thymoma and focal, esophageal myasthenia gravis. Surgical removal of the mass resulted in rapid resolution of the megaesophagus and a decrease in serum acetylcholine-receptor antibody concentration. The dog was clinically normal until the thymoma recurred six months postoperatively. Clinical signs, diagnostic evaluation, management, and treatment of a dog with thymoma and megaesophagus are described.

摘要

一只10岁已绝育的雄性可卡犬杂交犬出现反流、干呕和体重减轻。胸部X光片显示有一个大的纵隔肿块和食管扩张。细胞学、组织病理学、免疫组织化学和血清学检查结果与淋巴上皮性胸腺瘤和局灶性食管重症肌无力相符。手术切除肿块后，巨食管迅速消退，血清乙酰胆碱受体抗体浓度降低。这只狗术后临床症状正常，直到六个月后胸腺瘤复发。本文描述了一只患有胸腺瘤和巨食管犬的临床症状、诊断评估、管理和治疗情况。