Dhillon J S, Kronick J B, Singh N C, Johnson C C
Paediatric Critical Care Unit, Department of Paediatrics, Children's Hospital of Western Ontario, London, ON, Canada.
Crit Care Med. 1996 Jun;24(6):1068-71. doi: 10.1097/00003246-199606000-00030.
To evaluate a portable scavenging system for nitric oxide and its oxides, designed for use on neonatal transport.
A prospective evaluation of the nitric oxide scavenging system, using a neonatal transport incubator ventilator and a test lung.
Laboratory of a tertiary care children's hospital.
The scavenging system was tested, using a neonatal transport incubator with attached ventilator, ventilator circuit, and a neonatal test lung. Nitric oxide was administered on the inspiratory limb, and nitric oxide and its oxides were measured in the expiratory gas after passing through the scavenger.
A modified scrubber assembly was filled with 50% activated charcoal and 50% aluminas potassium permanganate pellets (3). Three wire meshes were placed before, in between, and after the two chemicals to facilitate gas flow. Using the maximum FIO2, with a nitric oxide concentration of 120 parts per million (ppm), the test lung continuous flow ventilation (FIO2 of 0.86, peak inspiratory pressure of 30 cm H2O, positive end-expiratory pressure of 6 cm H2O) and respiratory rate of 60 breaths/min) was performed for 4 hrs with each of four freshly prepared scavenging systems. A fifth scavenging system was tested for a 12-hr period. The mean composition of the exhaled gases for 4 hrs were: nitric oxide 0.01 +/- 0.03 (SD) ppm, nitric dioxide 0.06 +/- 0.06 ppm, and other oxides 0.05 +/- 0.09 ppm. After 12 hrs of 120 ppm of inhaled nitric oxide, the fifth scavenger system had undetectable nitric oxide, nitric dioxide, and other oxides in the exhaled gas. Normal room air contained between 0.0 and 0.03 ppm of nitric oxide, 0.0 and 0.02 ppm of nitric dioxide, and 0.0 and 0.02 ppm of other oxides.
Nitric oxide, nitric dioxide, and other dioxides can be safely scavenged by this portable scavenging system, allowing safe administration of nitric oxide free from environmental contamination with nitric oxide and its oxides.
评估一种用于新生儿转运的便携式一氧化氮及其氧化物清除系统。
使用新生儿转运暖箱呼吸机和测试肺对一氧化氮清除系统进行前瞻性评估。
一家三级儿童专科医院的实验室。
使用带有呼吸机、呼吸机回路和新生儿测试肺的新生儿转运暖箱对清除系统进行测试。在吸气支注入一氧化氮，并在气体通过清除器后测量呼气中的一氧化氮及其氧化物。
一个改良的洗涤器组件填充了50%的活性炭和50%的氧化铝高锰酸钾颗粒（3）。在这两种化学物质之前、中间和之后放置三个金属丝网以促进气流。使用最大吸入氧浓度，一氧化氮浓度为百万分之120（ppm），对四个新制备的清除系统分别进行测试，使测试肺以持续气流通气（吸入氧浓度0.86，吸气峰压30 cm H₂O，呼气末正压6 cm H₂O）和呼吸频率60次/分钟运行4小时。对第五个清除系统进行了12小时的测试。4小时呼出气体的平均成分如下：一氧化氮0.01±0.03（标准差）ppm，二氧化氮0.06±0.06 ppm，其他氧化物0.05±0.09 ppm。在吸入120 ppm一氧化氮12小时后，第五个清除系统呼出气体中的一氧化氮、二氧化氮和其他氧化物无法检测到。正常室内空气中一氧化氮含量在0.0至0.03 ppm之间，二氧化氮含量在0.0至0.02 ppm之间，其他氧化物含量在0.0至0.02 ppm之间。
该便携式清除系统可安全清除一氧化氮、二氧化氮和其他二氧化物，从而能够安全地使用一氧化氮，而不会造成一氧化氮及其氧化物对环境的污染。
