Reissmann E, Ernsberger U, Francis-West P H, Rueger D, Brickell P M, Rohrer H
Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.
Development. 1996 Jul;122(7):2079-88. doi: 10.1242/dev.122.7.2079.
The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. BMP-4 and BMP-7 are expressed in the dorsal aorta at critical times during sympathetic neuron differentiation and have the ability to enhance the formation of adrenergic sympathetic neurons both in cultures of neural crest cells and when ectopically expressed in the developing embryo.
交感神经元的神经递质表型由其与周围胚胎组织的相互作用所决定。在发育早期，靠近脊索和背主动脉的区域会引发肾上腺素能分化，并且轴向中线组织对肾上腺素能分化的重要性已有充分记载。我们现在提供证据表明，骨形态发生蛋白BMP - 4和BMP - 7是由背主动脉产生的信号，可指导交感神经元的分化。BMP - 4和BMP - 7在交感神经元分化的关键时期在背主动脉中表达，并且在神经嵴细胞培养物中以及在发育中的胚胎中异位表达时，都有能力增强肾上腺素能交感神经元的形成。
