Moreaud O, Naegele B, Chabannes J P, Roulin J L, Garbolino B, Pellat J
Service Neurologie et Neuropsychologie, CHRU, Grenoble.
Encephale. 1996 Jan-Feb;22(1):47-51.
A dysfunction of dorsolateral prefrontal cortex (DLPF) in major depression is suggested by functional imagery and comparative neuropsychology. However, assessment of frontal lobe syndrome with DLPF-dependent tests led to controversial results. To clarify these findings, we administered 5 of these tests (Wisconsin Card Sorting Test, Stroop Test, Trail Making Test, Tower of Toronto, verbal fluency) to 16 major depressive subjects and their 16 controls, before and after 21 days of treatment. Furthermore, we tried to assess the prognostic value of frontal lobe dysfunction, and its relation with the endogenous or exogenous nature of the depression on the one hand, the severity of the depression on the other hand. Our results suggest that the presence of a frontal lobe syndrome (defined by impaired performances at 3 tests or more) is only noted in endogenous depression; after treatment, no impairment is detected. No correlation is found with the severity of the depression. Frontal lobe syndrome does not seem to indicate poorer prognosis for current depressive episode.
功能影像学和比较神经心理学研究表明，重度抑郁症患者存在背外侧前额叶皮质（DLPF）功能障碍。然而，使用依赖于DLPF的测试来评估额叶综合征却得出了有争议的结果。为了阐明这些发现，我们在治疗前和治疗21天后，对16名重度抑郁患者及其16名对照者进行了其中5项测试（威斯康星卡片分类测试、斯特鲁普测试、连线测验、多伦多塔测试、语言流畅性测试）。此外，我们试图评估额叶功能障碍的预后价值，以及它一方面与抑郁症的内源性或外源性本质、另一方面与抑郁症严重程度之间的关系。我们的结果表明，仅在内源性抑郁症中发现存在额叶综合征（由三项或更多测试表现受损定义）；治疗后，未检测到功能障碍。未发现与抑郁症严重程度相关。额叶综合征似乎并不表明当前抑郁发作的预后较差。
