Bochmann D, Bahnsen J, Löning T, Böcker W
Abt. f. Gynäkologische Radiologie, Universitäts-Frauenklinik Hamburg-Eppendorf.
Geburtshilfe Frauenheilkd. 1996 Apr;56(4):204-8. doi: 10.1055/s-2007-1022260.
Lobular cancerisation was diagnosed in 101 women between 1976 and 1980. Calcification in the mammograms and follow-up without mastectomy were analysed. Therapy was simple biopsy, because the term lobular cancerisation was not established at that time. Surgery was done at the University Clinic for Women and the Elim Hospital at Hamburg. Retrospective analysis of the specimens was performed at the Department of Gynaecological Histopathology of the Hamburg University Clinic. Mammograms were available in 72 cases, showing calcifications in 40 cases. It was impossible to match the calcifications in the mammograms and the histological slides. Hence, a further 23 cases from 1980 to 1990 were analysed, suffering from lobular cancerisation and ductal carcinoma in situ (DCIS). Comparing 13 mammograms showing calcifications, with large-area scans, only two showed corresponding calcifications. Based on these data a specific diagnosis of lobular cancerisation by mammography is impossible. The follow-up of 88 patients with breast-preserving surgery and lobular cancerisation showed ipsilateral invasive carcinoma in three cases (0.35% in a total of 100 follow-up years), ipsilateral DCIS in five, and contralateral invasive breast cancer in one case. The therapy of lobular cancerisation should depend on the coexisting DCIS. There is no additional risk of local recurrence by lobular cancerisation.
1976年至1980年间，101名女性被诊断为小叶癌化。对乳房X光片中的钙化情况以及未进行乳房切除术的随访情况进行了分析。由于当时小叶癌化这一术语尚未确立，治疗方法为单纯活检。手术在汉堡大学妇女诊所和埃尔姆医院进行。汉堡大学诊所妇科组织病理学部门对标本进行了回顾性分析。72例患者有乳房X光片，其中40例显示有钙化。乳房X光片中的钙化与组织学切片无法匹配。因此，又分析了1980年至1990年间另外23例患有小叶癌化和导管原位癌（DCIS）的病例。将13张显示钙化的乳房X光片与大面积扫描结果进行比较，只有两张显示出相应的钙化。基于这些数据，通过乳房X光片对小叶癌化进行特异性诊断是不可能的。对88例行保乳手术且患有小叶癌化的患者进行随访，结果显示3例出现同侧浸润性癌（在总共100年的随访期内占0.35%），5例出现同侧DCIS，1例出现对侧浸润性乳腺癌。小叶癌化的治疗应取决于并存的DCIS。小叶癌化不会增加局部复发的额外风险。
