Leger-Ravet M B, Borgonovo G, Amato A, Lemaigre G, Franco D
Department of Pathology, Hopital Antoine Beclere, University of Paris XI, Clamart France.
Hepatogastroenterology. 1996 Jan-Feb;43(7):255-9.
Carcinosarcoma of the liver with mesenchymal differentiation are very rare in adult patients. A case is reported with an exhaustive pathologic examination and review of the literature. A 61-year old man presented with general fatigue and dull abdominal pain. Two liver masses were diagnosed and resected by a right hepatectomy. Specimen pathology revealed that the tumor and lymph node consisted of two cancerous components. One carcinomatous component corresponding to a hepatocellular carcinoma and a sarcomatous component characterized by a diffuse proliferation of spindle shaped cells with chondrosarcomatous and osteosarcomatous changes. Patient died 9 months later of a diffusion of the tumor. For the first time, to our knowledge, a mesenchymal differentiation is demonstrated in liver carcinosarcoma.
成人患者中具有间充质分化的肝脏癌肉瘤非常罕见。本文报告了一例病例，并进行了详尽的病理检查及文献复习。一名61岁男性患者出现全身乏力和腹部隐痛。经诊断有两个肝脏肿块，并通过右半肝切除术切除。标本病理显示肿瘤和淋巴结由两种癌性成分组成。一种癌性成分对应肝细胞癌，另一种肉瘤性成分的特征是梭形细胞弥漫性增殖，并伴有软骨肉瘤和骨肉瘤样改变。患者9个月后因肿瘤扩散死亡。据我们所知，首次在肝脏癌肉瘤中证实了间充质分化。
