Camilleri M, Saslow S B, Bharucha A E
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 1996 Mar;25(1):247-58. doi: 10.1016/s0889-8553(05)70374-5.
This article reviews the basic anatomy and physiology of visceral afferent function and its application to a clearer understanding of visceral pain and symptoms in patients with functional gastrointestinal disorders. Recent investigations have focused on the potential role of visceral tone, different afferent (A delta and C) fibers, dorsal column neurons, and supraspinal modulation in the elicitation of visceral perception of noxious and nonnoxious stimuli arising in the gut. Greater understanding of these pathomechansims and their pharmacologic manipulation offers an opportunity for future therapeutic strategies for these disorders.
本文综述了内脏传入功能的基本解剖学和生理学及其在更清晰理解功能性胃肠疾病患者的内脏疼痛和症状方面的应用。最近的研究集中在内脏张力、不同传入（Aδ和C）纤维、背柱神经元和脊髓上调制在引发肠道中有害和无害刺激的内脏感知方面的潜在作用。对这些病理机制及其药物操纵的更深入理解为这些疾病的未来治疗策略提供了机会。
