Division of Gastroenterology & Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA.
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Biomolecules. 2024 Jun 26;14(7):760. doi: 10.3390/biom14070760.
In the realm of gastroenterology, the inadequacy of current medical treatments for gastrointestinal (GI) motility disorders and inflammatory bowel disease (IBD), coupled with their potential side effects, necessitates novel therapeutic approaches. Neuromodulation, targeting the nervous system's control of GI functions, emerges as a promising alternative. This review explores the promising effects of vagal nerve stimulation (VNS), magnetic neuromodulation, and acupuncture in managing these challenging conditions. VNS offers targeted modulation of GI motility and inflammation, presenting a potential solution for patients not fully relieved from traditional medications. Magnetic neuromodulation, through non-invasive means, aims to enhance neurophysiological processes, showing promise in improving GI function and reducing inflammation. Acupuncture and electroacupuncture, grounded in traditional medicine yet validated by modern science, exert comprehensive effects on GI physiology via neuro-immune-endocrine mechanisms, offering relief from motility and inflammatory symptoms. This review highlights the need for further research to refine these interventions, emphasizing their prospective role in advancing patient-specific management strategies for GI motility disorders and IBD, thus paving the way for a new therapeutic paradigm.
在胃肠病学领域，当前用于治疗胃肠道（GI）动力障碍和炎症性肠病（IBD）的医学疗法存在不足，且可能存在副作用，因此需要新的治疗方法。神经调节作为一种有前途的替代方法，针对神经系统对 GI 功能的控制进行靶向调节。本综述探讨了迷走神经刺激（VNS）、磁神经调节和针灸在治疗这些具有挑战性疾病中的潜在作用。VNS 可针对 GI 运动和炎症进行靶向调节，为那些未从传统药物治疗中得到充分缓解的患者提供了一种潜在的解决方案。磁神经调节通过非侵入性手段，旨在增强神经生理过程，有望改善 GI 功能并减轻炎症。基于传统医学但又得到现代科学验证的针灸和电针通过神经-免疫-内分泌机制对 GI 生理学产生全面影响，从而缓解运动和炎症症状。本综述强调需要进一步研究来完善这些干预措施，并强调它们在推进针对 GI 动力障碍和 IBD 的个体化管理策略方面的预期作用，为新的治疗范例铺平道路。
