Lucchina L C, Kollias N, Gillies R, Phillips S B, Muccini J A, Stiller M J, Trancik R J, Drake L A
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
J Am Acad Dermatol. 1996 Jul;35(1):58-63. doi: 10.1016/S0190-9622(96)90497-1.
Quantification of acne remains a challenge. It may be difficult to identify lesions by standard flash photography. Previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin IX production by Propionibacterium acnes in open comedones, follicles, and inflammatory lesions.
Our purpose was to study the utility of fluorescence photography for evaluation of acne.
Forty subjects with mild to moderate acne vulgaris were randomly selected to apply either clindamycin 1% topical solution or vehicle twice daily. Counts of acne lesions and flash and fluorescence photographs were obtained at baseline, and at 4, 8, and 12 weeks.
At 12 weeks, the treatment group had a larger percentage change in open comedones, less fluorescence in all areas assessed, and a larger percent decrease in fluorescence than the vehicle group.
Fluorescence photography appears to be a useful tool to chart the course of acne treatment.
痤疮的量化仍然是一项挑战。通过标准闪光摄影识别皮损可能存在困难。先前的研究表明，荧光照片中的亮点对应于开放性粉刺、毛囊和炎性皮损中痤疮丙酸杆菌产生的高浓度原卟啉IX。
我们的目的是研究荧光摄影在痤疮评估中的效用。
随机选择40例轻至中度寻常痤疮患者，每天两次外用1%克林霉素溶液或赋形剂。在基线、4周、8周和12周时获取痤疮皮损计数以及闪光和荧光照片。
在12周时，治疗组开放性粉刺的百分比变化更大，所有评估区域的荧光更少，且荧光降低的百分比大于赋形剂组。
荧光摄影似乎是记录痤疮治疗过程的有用工具。
