Vaidya P, Kawarada Y, Higashiguchi T, Yoshida T, Sakakura T, Yatani R
First Department of Surgery, Mie University School of Medicine, Tsu, Japan.
J Pathol. 1996 Feb;178(2):140-5. doi: 10.1002/(SICI)1096-9896(199602)178:2<140::AID-PATH450>3.0.CO;2-U.
The expression of epidermal growth factor receptor (EGFR), c-erbB-2, and c-erbB-3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki-67-positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type I growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c-erbB-3 was significantly higher than with overexpression of c-erbB-2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c-erbB-2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c-erbB-3 in pancreatic head carcinoma and overexpression of c-erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases. Moreover, the overexpression of c-erb-3 in pancreatic head carcinoma, c-erb-2 in ampulla of Vater carcinoma, and Ki-67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type I growth factor receptor family are overexpressed in different carcinomas of the periampullary region.
采用免疫组织化学方法检测了57例壶腹周围癌组织中表皮生长因子受体（EGFR）、c-erbB-2和c-erbB-3的表达情况。同时检测了同一组织中Ki-67阳性细胞的百分比，以确定I型生长因子受体家族成员的表达与细胞增殖之间的关系。在胰腺癌中，c-erbB-3过表达病例的百分比显著高于c-erbB-2和EGFR过表达病例。相反，在低位胆管癌和 Vater壶腹癌中，c-erbB-2过表达病例的百分比高于其他生长因子受体过表达病例。在Ki-67抗原阳性病例中，胰腺癌中c-erbB-3过表达和Vater壶腹癌中c-erbB-2过表达的病例百分比更高。此外，胰腺癌中c-erb-3过表达、Vater壶腹癌中c-erb-2过表达以及两种癌症中Ki-67过表达均与患者预后不良相关。这些结果表明，I型生长因子受体家族的不同成员在壶腹周围区域的不同癌症中过表达。
