Zauner A, Bullock R
Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
J Neurotrauma. 1995 Aug;12(4):547-54. doi: 10.1089/neu.1995.12.547.
Severe brain trauma remains poorly understood, because of its pathophysiological complexity, and this has so far thwarted our attempts to improve outcome by means of drug therapy, although better understanding of the role of ischemic events has led to improved mortality rates, in some centers. With regard to excitatory amino acid antagonists, new mechanistic insights from both animal models, and human monitoring has enabled better trial design, which may allow the tremendous laboratory neuroprotective potency of this group of compounds to be translated to clinical benefit.
由于其病理生理复杂性，严重脑外伤目前仍未被充分了解，这阻碍了我们通过药物治疗改善预后的尝试，尽管对缺血事件作用的更好理解已使部分中心的死亡率有所降低。关于兴奋性氨基酸拮抗剂，动物模型和人体监测方面新的机制性见解使得试验设计得以优化，这可能会让这类化合物强大的实验室神经保护效能转化为临床益处。
