Reimann I, Mankin H J, Trahan C
Acta Orthop Scand. 1977 May;48(1):63-73. doi: 10.3109/17453677708985113.
Twelve femoral heads (two normal, four after fracture and six osteo-arthritic) were obtained at surgery or autopsy. Circumferential slices were obtained and five separate areas were analyzed in each for ash content; histological-histochemical grading of the severity of the cartilage changes; and quantitative morphometric analyses to establish the percentage of trabecular area, osteoblastic area and osteoclastic area. Analyses were performed to compare weight-bearing and non-weight-bearing areas of the femoral heads and to determine correlations between the bony and cartilaginous alterations. The data obtained showed wide variations in all parameters in the osteoarthritic specimens but consistently more marked cartilage and bony changes in the weight-bearing areas. Bone structures and metabolic parameters were distinctly increased for the osteoarthrities, differing significantly from both normal and fracture control groups. The bony change correlated directly with the severity of the cartilage lesions, as determined by the histological-histochemical grade.
通过手术或尸检获取了十二个股骨头（两个正常、四个骨折后和六个骨关节炎的）。获取了圆周切片，并对每个切片的五个不同区域进行了分析，以测定灰分含量；对软骨变化的严重程度进行组织学 - 组织化学分级；并进行定量形态计量分析以确定小梁面积、成骨细胞面积和破骨细胞面积的百分比。进行分析以比较股骨头的负重区和非负重区，并确定骨和软骨改变之间的相关性。所获得的数据显示，骨关节炎标本的所有参数存在广泛差异，但负重区的软骨和骨变化始终更为明显。骨关节炎患者的骨结构和代谢参数明显增加，与正常和骨折对照组均有显著差异。如组织学 - 组织化学分级所确定的，骨改变与软骨损伤的严重程度直接相关。
